RAF Tornado jets were deployed to bomb a Syrian chemical weapons factory in what has been hailed as a "highly successful mission".
The UK joined its military might with the US and France to launch to revenge strike against President Assad's regime following a chemical attack on civilians.
The RAF jets were deployed to strike a weapons factor
Four Tornado jets were deployed at 1am.
They fired Storm Shadow missiles at the chemical weapons factory base, which is 15 miles west of Homs.
The deadly precision missiles were chosen because they could "maximise destruction".
The factory is a former missile base and is believed to be where the Syrian regime keeps "chemical weapons precursors".
A spokesman for the MoD said: "Initial indications are that the precision of the Storm Shadow weapons and meticulous target planning have resulted in a successful attack.
"Very careful scientific analysis was applied to determine where best to target the Storm Shadows to maximise the destruction of the stockpiled chemicals and to minimise the destruction of the stockpiled chemicals and to minimise any risks of contamination to the surrounding area.
"The facility which was struck is located some distance from any known concentrations of civilian habitation, reducing yet further any such risk."
The MoD is investigating the aftermath of a precision hit aimed at wiping out Assad's deadly weapons which left 75 people dead on April 7.
Explosions have been reported in Damascus, just hours after Donald Trump confirmed he had ordered coalition airstrikes.
Pictures show the sky glowing a fiery orange and there were reports of blasts over Mount Qasioun.
Pro-Assad officials says around 30 missiles were fired at Syria during the attack, and a third were shot down with defence canons.
It claims three civilians were killed in the strikes.
Theresa May has said she had "no alternative" but to launch the airstrikes.
A statement read: "A significant body of information, including intelligence, indicates that the Syrian regime was responsible.
"This pattern of behaviour must be stopped
"Our action is proportionate, specifically aimed at degrading the regime’s ability to use chemical weapons and deterring further such appalling acts."
The MoD said the bombed facility was located some distance from any known concentrations of civilian habitation.
The statement adds: "Initial indications are that the precision of the Storm Shadow weapons and meticulous target planning have resulted in a successful attack."
Defence Secretary Gavin Williamson said: "The reprehensible use of chemical weapons in Douma is further evidence of the Syrian regime’s appalling cruelty against its own people.
"We will not stand by whilst innocent civilians, including women and children, are killed and made to suffer.
“The international community has responded decisively with legal and proportionate military force.
"Let these united actions send a clear message to the regime – the use of chemical weapons is categorically unacceptable and you will be held to account.”
Theresa May said there was 'no practicable alternative to the use of force' after the President announced the retaliation to reports of chemical attacks.
Trump said British and French military forces had joined the response as revenge for what he called "the crimes of a monster".
He also sent a stern message to Iran and Russia, with some fearing rising tensions could lead to World War 3.
"What kind of a nation wants to be associated with the mass murder of innocent men, women and children," he said.
"No nation can succeed by promoting rogue states and dictators."
He added: "Russia must decide whether to continue on this dark path or come back to civilisation."
The US Navy aircraft carrier USS Harry Truman departs with its strike group towards Syria from